Unequivocal

Aluminium is significantly increased in human brain tissue in Alzheimer's disease, multiple sclerosis and autism

This is a repeat of my previous post. While it was posted on the 5th of April it has yet to be sent to my subscribers. I cannot get a response from Substack as to why.

Just two years ago we published research in Nature’s Scientific Reports that unequivocally established significantly higher content of brain aluminium in Alzheimer’s disease, multiple sclerosis and autism. Data from these tissues were compared with human brain tissue from donors who died without any form of neurological disease or identifiable neurodegeneration. The paper was, of course, completely ignored by mainstream media ( https://www.nature.com/articles/s41598-020-64734-6 . In spite of this it has been accessed 58k times on the journal website and it is ranked number one by Altmetric (online attention monitor) of articles published in Scientific Reports over the past two years.

The aluminium content of human brain tissue may not prove a role for aluminium in disease but, at the very least, it should be a red flag for that disease. The data are not balancing on a knife edge of statistical significance. They prove highly statistically significant differences for each of Alzheimer’s disease, multiple sclerosis and autism. The data are unequivocal in their message and, at a different time in science when science and not politics mattered, the data would have caused a tsunami of interest in aluminium and human brain disease. Multiple research groups across the planet would be lining up to repeat the research. Funding would not be an issue as governments and charities alike would strive to prove or disprove a role for aluminium in these common human diseases. Diseases that together bring more pain and suffering to humankind than any other natural or manmade event or atrocity. Below I have copied the concluding paragraph of the paper. I wonder how many years, decades before it is acted upon.

Aluminium is not a member of the human metallome. However, its omnipresence in human tissue and especially the brain cannot be without consequence. It is only inimical to life, there is no homeostasis, and it is always a burden to life’s processes. Every atom of aluminium in human brain tissue must be accommodated as aluminium as Al3+(aq), is highly biologically reactive. Life is robust and some aluminium in human brain tissue is tolerated without overt effects. We need to define such limits in the terms of both quantity and location and we need to be more fully aware of human exposure to aluminium. We may then live healthily in the aluminium age (https://www.hippocraticpost.com/mens-health/the-aluminium-age/).