Just over two years ago my post ‘Cancelled Science’ was sent to 26 recipients and up to today has received 333 views.
My most recent post was sent to 4510 recipients and has already been viewed 3290 times. The burgeoning power of substack, long may it continue.
However, I am raising the subject of my earlier post because it included our latest data on Parkinson’s disease before the untimely closure of my laboratory. I am guessing that Parkinson’s disease may be something of interest for my substack subscribers. Parkinson’s disease (PD) shares some disease aetiology with Alzheimer’s disease and specifically the appearance of neurofibrillary tangles (NFT), often associated with the onset of dementia in PD. We have studied NFTs in a number of neurodegenerative diseases and specifically the association between aluminium and NFTs. We published our research in the Journal of Alzheimer's Disease. In this research we identified a very specific neuropathology in PD, a close relationship between something called Biondi ring tangles and aluminium. We decided to study this further and published our findings in the journal Scientific Reports. I have reproduced Figure 6 from this publication below.
Figure 6. Aluminium is co-deposited with thioflavin S (ThS) reactive Biondi tangles in ependymal cells of a 76-year-old female donor with Parkinson’s disease. (a) Aluminium (Al) fluorescence was observed in ependymal cells of pia mater lining the lateral ventricle with intense orange/yellow fluorescence in Biondi ring tangles (white arrows). (b) Cytoplasmic ThS-reactive Biondi ring tangles were identified in ependymal cells in an adjacent section. (c) DAB immunolabelling (black arrows) of phosphorylated tau (pTau) in identical ependymal cell nuclei. (d) Merging of the brightfield channel with UV induced autofluorescence demonstrated proteinaceous Biondi tangles in cell cytosol with pTau localised to cell nuclei. Asterisks denote magnified inserts. Magnification: . 400, scale bars: 50 μm.
The jury is still out on the role played by aluminium in Parkinson’s disease. Our limited quantitative analyses are equivocal and there is also the proviso that we did not have access to tissue from the substantia nigra, the area of the brain most affected in PD. However, our microscopy is not equivocal and demonstrates relationships between aluminium and neuropathology in PD. I am hoping that someone will take up the challenge of a role for aluminium in the aetiology of Parkinson’s disease. Just perhaps because it is a leap year someone just has to do this.
(quote): "I am guessing that Parkinson’s disease may be something of interest for my substack subscribers." (end of quote).
Yes. You are right. I am both a reader of your Dr´r Newsletter and interested in the disease, as I am diagnosed with Parkinson’s Disease in 1998. But I go my own way and do not use Parkinson medication, which only suppress the symptoms. I try to treat the causes, which I have had success with (it is not easy and it is still not easy). You can read about me here:
https://www.mercurymadness.org/Case-Study-of-Hanne-Koplev---Veterinarian--Denmark--Diagnosed-with-Parkinson-s-Disease--nw244.aspx
I have been treated for allergy many years ago using subcutaneous injections, which contains enormous amount of aluminium. It is my impression, that aluminium is not easily chelated with DMPS, DMSA or D-penicillamine, if at all, but I might be wrong.
My cousin suddenly developed PD after the 2021 injections and just died in December. He had been a pilot for 40 years.