Reading this, I felt like watching an excellent episode of a marvellous film series. You’ve sketched a vivid scenario with a few sentences, and you left the finale to rise above the whole series as if accidentally. Only hinting at the potential for sequels...
I am not a specialist in your field, but I can recognize and appreciate your eloquence with the subject and your readiness to share its beauty with lay people like me. Thank you for letting us all in your lab and giving us a tour. In all your articles or interviews.
Your book would easily translate to a riveting screenplay: more sinister intrigue, unique discoveries and "the forces of good combating the forces of evil" than any work of fiction!
-- a very interesting story of discovery Dr Exley. Following the thread of this over so many years in your long pursuit finally obtaining vindication, a great reward. Thank you for sharing this with the world.
Whichever is better excreted via glomerular filtration.
Any chance of soon removing aluminium compounds from the GRAS (Generally Recognized As Safe) list for food, water, injectables, and cosmetics or whatever deodorants are classified as? Is that on RFK, Jr.'s radar?
“…almost another Thirty Years …” War of the Roses versus the Thorns - or Thrones, Game Of.
How many forms of status quo-metries I wonder, because it looks to me like there is only the one.
And it looks to me like anything can be done with, & has been done with, the fable of the Tortoise & the Hare.
I kinda like this version, but flipped so that the Tortoise gives Achilles (“an easy kill”) the head start. Well, “gives.”
“In Classical times, the story was annexed to a philosophical problem by Zeno of Elea in one of many demonstrations that movement is impossible to define satisfactorily. The second of Zeno's paradoxes is that of Achilles and the Tortoise, in which the hero gives the Tortoise a head start in a race. The argument attempts to show that even though Achilles runs faster than the Tortoise, he will never catch up with her because, when Achilles reaches the point at which the Tortoise started, the Tortoise has advanced some distance beyond; when Achilles arrives at the point where the Tortoise was when Achilles arrived at the point where the Tortoise started, the Tortoise has again moved forward. Hence Achilles can never catch the Tortoise, no matter how fast he runs, since the Tortoise will always be moving ahead.[9][10]
The only satisfactory refutation has been mathematical and since then the name of the fable has been applied to the function described in Zeno's paradox. In mathematics and computer science, the tortoise and the hare algorithm is an alternative name for Floyd's cycle-finding algorithm."
Here I’d mention, just, things like those economistoes that inform us that, via hedonic algorithms, the price of cars has “actually” not increased, at all, for a long time & tongue-in-groove manufacturers/govs designing automated/remote kill switches into cars from ’26 forward.
Like Schwartzeneggar said: “Screw your heels & toes!”
I comm’d with an author recently. His latest is out & the link for it, like for damn near everything else too, put amazon in the middle, & my query went to removing that middle-against-both-ends. His reply was that amazon is pretty much the game, but that I could order thru Barnes & Nobles.
“I have no choice, I gotta amazon!”
“I have no choice, I gotta pandemic!” Had much to do with that roll(ing on the river) up.
Achilles says “if you can’t beat ‘em join ‘em” which translates to “if you can’t not join them they will beat you - every time.”
And once your enjoin eventuates in “I am become Death, the Destroyer of Worlds,” it is well past too late.
“I’m late! I’m late!” ~ another rabbit
So there’s mad pursuits & there’s mad pursuits.
I am all for, & fully participation-invested, in the one (that isn’t unicycle).
It's great that you were able to find out what best binds to aluminum. Maybe one day it can be synthesized instead of needing to rely on getting water shipped across the world.
2025 will be exciting... The stage has been set with many revealing things so far, such as the fluoride trial in the USA.
One thing that hopefully will be examined deeper, genetics.
The DNA discovery was fraught with bad methods and huge assumptions.
"It documents Barry Scheck and Greg Hampkian’s efforts to bring some kind of accuracy testing by the government agencies such as NIST. They, after some cajoling FORCED them into doing a blinded accuracy study. They took a sample of 3 different suspects, they knew which was the perpetrator and asked 108 different labs to find it.
The results were SHOCKING….. the claim that DNA genetics analysis is 99.8% accurate was SLASHED to just 6% getting the correct answer!!!!! The worst thing about it… if they had just taken a wild guess, they would have been right 33% of the time… so the genetics test was WORSE than just randomly guessing."
Gosh! Interesting - but I haven't got time to dissect it properly to come to a proper view.
I'm open minded about it because some years ago I fell into a heated [discussion] about the reliability of polygraph tests. IMO they were bolleaux & nothing I've seen since has changed my mind.
Of no surprise, almost without exception, my chronically ill clients are deficient in silica, using an interesting test, Oligoscan. Silica, methylation, and sulfation pathways are all critical to moving metals out of our body. Toxic metal substitution occurs frequently for those deficient in key minerals. Basic nutritional status, minerals being one category is fundamental to a well functioning system. When we think of the human genome, with over 20,000 genes, and almost very gene has a co factor, around 200 to 400 unique cofactors, each deficiency in a cofactor shuts down 50 to 100 genes. For the most common cofactors like magnesium and NAD this number approaches 500.
Yes, it's our job as citizen scientists to question all this. There has been a problem with the notion of a virus ever since Beijerinck (1898) proposed viruses caused tobacco mosaic disease. Virologists tell us that 130 billion virions in 1 mL of bodily fluids is not enough to see under electron microscopy so we have to culture them in a soup - or run dubious "sequencing" (also on a soup).
I am even beginning to question the DNA thing. As far as I know, it's all computer algorithms and guesswork. No magnification can touch it. That means anything can be invented and called DNA, just like viruses and so much else in science.
Could you please elucidate why you posit, without HAS there would be no DNA? Did I miss something in your book about ubiquitous aluminum doing something horrid to DNA?
Without the formation of HAS as part of the Al geochemical cycle, Al would be biologically available and therefore prevent the advent of (DNA-based) life on Earth.
So silicon and therefore silicates are kind of necessary for Life as we know it?
I remember back to school and Uni where we were told "CHONPS" was what Life was all about: Carbon, Hydrogen, Oxygen, Nitrogen, Phosphorus and Sulfur. I guess they forgot - or never thought - that without Si, none of it would even be possible?!
There's altogether too much small-mindedness in both science & education these days.
It's not in the book under DNA but you can find Sperm Count on pg 62 and on pg 90 the table provides a rough idea of the high correlation of aluminium to fertility problems.
Aluminum 3+ ions are notorious for their power to destabilise most biological compounds. Perhaps a more nuanced view is that AL 3+ is "cross linking" DNA strands? So on that point, here is a snippet from "Some effects of metal ions on DNA structure and genetic information transfer". G. L. EICHHORN, J. J. BUTZOW and Υ. A. SHIN
"We have noted that base-binding metal ions destabilize the DNA double helix. The
reason for this destabilization is readily apparent when we consider that the metal ions
can compete with the hydrogens in the hydrogen bonds for the electron donor sites on
the bases. By displacing hydrogen bonds the metals can then form crosslinks between
the strands (Eichhorn, 1981). We have recently discovered that aluminum ions form
crosslinks between DNA strands (Karlik et al., 1980). This discovery may be of
particular interest because of the apparent correlation between Alzheimer's disease, the
most prevalent form of senile dementia, and the accumulation of aluminum in the brain
in relatively high concentration (Crapper et al., 1973).
What about additional diseases and genetic defects of the baby conceived from a father and mother poisoned by this metal? Perhaps a few chugs of silicon-rich "bubbly" are in order before dancing too close?
A rebuttal to a troll?!! In science if you disagree with something published in a paper you write a letter to the editor of the journal that published the paper. The editor then invites the author of the criticised paper to respond. No scientist has ever written a letter to the editor concerning our seminal paper in Metallomics.
I watched the film and checked out the original paper. Thanks for the recommendation since I haven't watched a movie for over a year.
It's interesting that the original Crick & Watson paper states. "As the phosphates are on
the outside, cations have easy access to them". So this certainly supports the idea that a powerful cation like Al3+ would have easy access to these outside groups. I would speculate that other (metal) cations like iron and calcium with a less intense positive charge might also have access but apparently not the power to blow up (or cross link) the chain.
Related to this, on page 17 of Imagine You Are An Aluminium Atom reminds us that not only does calcium react with phosphate groups in the bone (good) but also with aluminium (bad).
I couldn't help notice that Watson is portrayed as a "gum chewing American". I have worked and lived with hundreds of Americans and I can't remember more than a couple of them (teenagers) who incessantly chewed gum.
It was interesting to be reminded of smoked filled staff rooms which were in every school. My only major achievement while studying chemistry at University was to get smoking banned in the meeting rooms. Fingers crossed for a better New Year for all of us.
Has anyone repeated the Watson - Crick - Franklin experiments to corroborate their findings?Was DNA's structure verified later by more advanced techniques?
Reading this, I felt like watching an excellent episode of a marvellous film series. You’ve sketched a vivid scenario with a few sentences, and you left the finale to rise above the whole series as if accidentally. Only hinting at the potential for sequels...
I am not a specialist in your field, but I can recognize and appreciate your eloquence with the subject and your readiness to share its beauty with lay people like me. Thank you for letting us all in your lab and giving us a tour. In all your articles or interviews.
Have a great New Year.
Regards, Dan
Thank you Dan, perhaps my friend and film maker Bert Ehgartner might put some flesh on the bones of this old story teller.
Your book would easily translate to a riveting screenplay: more sinister intrigue, unique discoveries and "the forces of good combating the forces of evil" than any work of fiction!
Very well said, Dan. You, also, eloquent!
How lucky the world is to have you as our teacher.
Indeed!
-- a very interesting story of discovery Dr Exley. Following the thread of this over so many years in your long pursuit finally obtaining vindication, a great reward. Thank you for sharing this with the world.
I too hope you the best in this coming New Year.
Have a wonderful new year!
Is it better for the body to get rid of aluminium as HASa than to get rid of it in HASb?
Experience but alas not experiment suggests to me that the success of silicon-rich water is in forming the more stable HASB.
Whichever is better excreted via glomerular filtration.
Any chance of soon removing aluminium compounds from the GRAS (Generally Recognized As Safe) list for food, water, injectables, and cosmetics or whatever deodorants are classified as? Is that on RFK, Jr.'s radar?
Another year closer to the vindication of our cancelled heroes.
“…almost another Thirty Years …” War of the Roses versus the Thorns - or Thrones, Game Of.
How many forms of status quo-metries I wonder, because it looks to me like there is only the one.
And it looks to me like anything can be done with, & has been done with, the fable of the Tortoise & the Hare.
I kinda like this version, but flipped so that the Tortoise gives Achilles (“an easy kill”) the head start. Well, “gives.”
“In Classical times, the story was annexed to a philosophical problem by Zeno of Elea in one of many demonstrations that movement is impossible to define satisfactorily. The second of Zeno's paradoxes is that of Achilles and the Tortoise, in which the hero gives the Tortoise a head start in a race. The argument attempts to show that even though Achilles runs faster than the Tortoise, he will never catch up with her because, when Achilles reaches the point at which the Tortoise started, the Tortoise has advanced some distance beyond; when Achilles arrives at the point where the Tortoise was when Achilles arrived at the point where the Tortoise started, the Tortoise has again moved forward. Hence Achilles can never catch the Tortoise, no matter how fast he runs, since the Tortoise will always be moving ahead.[9][10]
The only satisfactory refutation has been mathematical and since then the name of the fable has been applied to the function described in Zeno's paradox. In mathematics and computer science, the tortoise and the hare algorithm is an alternative name for Floyd's cycle-finding algorithm."
Cycles. Plural?
https://i.pinimg.com/originals/2e/c3/de/2ec3de0350e046113e4b3ae6ea2ded85.jpg
Finding that heel, for the heal, is so slow because so many toes are on the throttling throttle that the unicyclists pay them to fetish.
https://www.youtube.com/watch?v=nrQHPz87FP0
Here I’d mention, just, things like those economistoes that inform us that, via hedonic algorithms, the price of cars has “actually” not increased, at all, for a long time & tongue-in-groove manufacturers/govs designing automated/remote kill switches into cars from ’26 forward.
Like Schwartzeneggar said: “Screw your heels & toes!”
https://www.ericpetersautos.com/2023/02/14/this-kill-switch-business/
I comm’d with an author recently. His latest is out & the link for it, like for damn near everything else too, put amazon in the middle, & my query went to removing that middle-against-both-ends. His reply was that amazon is pretty much the game, but that I could order thru Barnes & Nobles.
“I have no choice, I gotta amazon!”
“I have no choice, I gotta pandemic!” Had much to do with that roll(ing on the river) up.
Achilles says “if you can’t beat ‘em join ‘em” which translates to “if you can’t not join them they will beat you - every time.”
And once your enjoin eventuates in “I am become Death, the Destroyer of Worlds,” it is well past too late.
“I’m late! I’m late!” ~ another rabbit
So there’s mad pursuits & there’s mad pursuits.
I am all for, & fully participation-invested, in the one (that isn’t unicycle).
Trick question: “Aye, but which is which?” ::
https://www.youtube.com/watch?v=ESYU-bkmxuI
I wonder if the Amish amazon? If some do, not Erudite-Luddite enough.
It's great that you were able to find out what best binds to aluminum. Maybe one day it can be synthesized instead of needing to rely on getting water shipped across the world.
2025 will be exciting... The stage has been set with many revealing things so far, such as the fluoride trial in the USA.
One thing that hopefully will be examined deeper, genetics.
The DNA discovery was fraught with bad methods and huge assumptions.
https://criticalcheck.wordpress.com/2021/12/15/dna-discovery-extraction-and-structure-a-critical-review/
And the result of genetics is shoddy at best... Examples here
https://controlstudies.substack.com/p/the-dna-hoax-0a2
"It documents Barry Scheck and Greg Hampkian’s efforts to bring some kind of accuracy testing by the government agencies such as NIST. They, after some cajoling FORCED them into doing a blinded accuracy study. They took a sample of 3 different suspects, they knew which was the perpetrator and asked 108 different labs to find it.
The results were SHOCKING….. the claim that DNA genetics analysis is 99.8% accurate was SLASHED to just 6% getting the correct answer!!!!! The worst thing about it… if they had just taken a wild guess, they would have been right 33% of the time… so the genetics test was WORSE than just randomly guessing."
Gosh! Interesting - but I haven't got time to dissect it properly to come to a proper view.
I'm open minded about it because some years ago I fell into a heated [discussion] about the reliability of polygraph tests. IMO they were bolleaux & nothing I've seen since has changed my mind.
I heard that polygraph can show true when a psychopath lies because at the time they believe it.
As for other tests, I think the ptb assumed too many things on how to fool humanity... So many of their plans were based on rigged studies lol.
https://robc137.substack.com/p/the-milgram-experiment-and-how-we
Of no surprise, almost without exception, my chronically ill clients are deficient in silica, using an interesting test, Oligoscan. Silica, methylation, and sulfation pathways are all critical to moving metals out of our body. Toxic metal substitution occurs frequently for those deficient in key minerals. Basic nutritional status, minerals being one category is fundamental to a well functioning system. When we think of the human genome, with over 20,000 genes, and almost very gene has a co factor, around 200 to 400 unique cofactors, each deficiency in a cofactor shuts down 50 to 100 genes. For the most common cofactors like magnesium and NAD this number approaches 500.
Happy New Year Dr Exley. Since I have still not found evidence/isolation of a Covid19 virus, I now wonder about the human genome project.
Yes, it's our job as citizen scientists to question all this. There has been a problem with the notion of a virus ever since Beijerinck (1898) proposed viruses caused tobacco mosaic disease. Virologists tell us that 130 billion virions in 1 mL of bodily fluids is not enough to see under electron microscopy so we have to culture them in a soup - or run dubious "sequencing" (also on a soup).
I am even beginning to question the DNA thing. As far as I know, it's all computer algorithms and guesswork. No magnification can touch it. That means anything can be invented and called DNA, just like viruses and so much else in science.
Watch the film in my post.
Atomic force microscopy can't image it?
Could you please elucidate why you posit, without HAS there would be no DNA? Did I miss something in your book about ubiquitous aluminum doing something horrid to DNA?
Without the formation of HAS as part of the Al geochemical cycle, Al would be biologically available and therefore prevent the advent of (DNA-based) life on Earth.
So silicon and therefore silicates are kind of necessary for Life as we know it?
I remember back to school and Uni where we were told "CHONPS" was what Life was all about: Carbon, Hydrogen, Oxygen, Nitrogen, Phosphorus and Sulfur. I guess they forgot - or never thought - that without Si, none of it would even be possible?!
There's altogether too much small-mindedness in both science & education these days.
Thankyou for your invigorating post!!
Unfortunately, we, in our ignorance, invented a way to make it biologically available.
That is absolutely mind-blowing. Beautiful science. Beautiful post. Thank you.
It's not in the book under DNA but you can find Sperm Count on pg 62 and on pg 90 the table provides a rough idea of the high correlation of aluminium to fertility problems.
Aluminum 3+ ions are notorious for their power to destabilise most biological compounds. Perhaps a more nuanced view is that AL 3+ is "cross linking" DNA strands? So on that point, here is a snippet from "Some effects of metal ions on DNA structure and genetic information transfer". G. L. EICHHORN, J. J. BUTZOW and Υ. A. SHIN
"We have noted that base-binding metal ions destabilize the DNA double helix. The
reason for this destabilization is readily apparent when we consider that the metal ions
can compete with the hydrogens in the hydrogen bonds for the electron donor sites on
the bases. By displacing hydrogen bonds the metals can then form crosslinks between
the strands (Eichhorn, 1981). We have recently discovered that aluminum ions form
crosslinks between DNA strands (Karlik et al., 1980). This discovery may be of
particular interest because of the apparent correlation between Alzheimer's disease, the
most prevalent form of senile dementia, and the accumulation of aluminum in the brain
in relatively high concentration (Crapper et al., 1973).
What about additional diseases and genetic defects of the baby conceived from a father and mother poisoned by this metal? Perhaps a few chugs of silicon-rich "bubbly" are in order before dancing too close?
The https://sciencebasedmedicine.org/ smearers have joined forces with the reckless aluminium industry to get you and me. Apparently 7 years ago, so you're probably already well aware of it. https://www.respectfulinsolence.com/2017/11/29/christopher-exley-using-bad-science-to-demonize-aluminum-adjuvants-in-vaccines/
This showed up on NextDoor.com
Yes indeed!
Have you written a rebuttal, esp. regarding your alleged bad data as
https://pubmed.ncbi.nlm.nih.gov/22045115/
https://academic.oup.com/metallomics/article-abstract/4/1/56/6016058
and
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad00432
are supposed to cite? I haven't obtained the source text of those paywalled articles yet.
A rebuttal to a troll?!! In science if you disagree with something published in a paper you write a letter to the editor of the journal that published the paper. The editor then invites the author of the criticised paper to respond. No scientist has ever written a letter to the editor concerning our seminal paper in Metallomics.
I watched the film and checked out the original paper. Thanks for the recommendation since I haven't watched a movie for over a year.
It's interesting that the original Crick & Watson paper states. "As the phosphates are on
the outside, cations have easy access to them". So this certainly supports the idea that a powerful cation like Al3+ would have easy access to these outside groups. I would speculate that other (metal) cations like iron and calcium with a less intense positive charge might also have access but apparently not the power to blow up (or cross link) the chain.
Related to this, on page 17 of Imagine You Are An Aluminium Atom reminds us that not only does calcium react with phosphate groups in the bone (good) but also with aluminium (bad).
I couldn't help notice that Watson is portrayed as a "gum chewing American". I have worked and lived with hundreds of Americans and I can't remember more than a couple of them (teenagers) who incessantly chewed gum.
It was interesting to be reminded of smoked filled staff rooms which were in every school. My only major achievement while studying chemistry at University was to get smoking banned in the meeting rooms. Fingers crossed for a better New Year for all of us.
I enjoyed the post. Thankyou.
Has anyone repeated the Watson - Crick - Franklin experiments to corroborate their findings?Was DNA's structure verified later by more advanced techniques?
I think the structure of DNA has been studied more often than any other molecule.